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Titre : Ferroptosis of Microglia in Aging Human White Matter Injury Type de document : texte imprimé Auteurs : Philip A. Adeniyi (19.. - ....), Auteur ; Xi Gong (19.. - ....), Auteur ; Ellie MacGregor (19.. - ....), Auteur Editeur : New Jersey [États-Unis] : John Wiley & Sons Année de publication : 2023 Collection : Annals of Neurology, ISSN 0364-5134 Importance : 19 p. Présentation : ill. en coul. Format : 30cm Langues : Anglais Langues originales : Anglais Catégories : Démences:Maladie d'Alzheimer
Sciences:RechercheTags : Recherche médicale, Microglies, Alzheimer Résumé :
Abstract
Objective
Because the role of white matter (WM) degenerating microglia (DM) in remyelination failure is unclear, we sought to define the core features of this novel population of aging human microglia.
Methods
We analyzed postmortem human brain tissue to define a population of DM in aging WM lesions. We used immunofluorescence staining and gene expression analysis to investigate molecular mechanisms related to the degeneration of DM.
Results
We found that DM, which accumulated myelin debris were selectively enriched in the iron-binding protein light chain ferritin, and accumulated PLIN2-labeled lipid droplets. DM displayed lipid peroxidation injury and enhanced expression for TOM20, a mitochondrial translocase, and a sensor of oxidative stress. DM also displayed enhanced expression of the DNA fragmentation marker phospho-histone H2A.X. We identified a unique set of ferroptosis-related genes involving iron-mediated lipid dysmetabolism and oxidative stress that were preferentially expressed in WM injury relative to gray matter neurodegeneration.
Interpretation
Ferroptosis appears to be a major mechanism of WM injury in Alzheimer's disease and vascular dementia. WM DM are a novel therapeutic target to potentially reduce the impact of WM injury and myelin loss on the progression of cognitive impairment. ANN NEUROL 2023
En ligne : https://doi.org/10.1002/ana.26770 Ferroptosis of Microglia in Aging Human White Matter Injury [texte imprimé] / Philip A. Adeniyi (19.. - ....), Auteur ; Xi Gong (19.. - ....), Auteur ; Ellie MacGregor (19.. - ....), Auteur . - New Jersey (États-Unis) : John Wiley & Sons, 2023 . - 19 p. : ill. en coul. ; 30cm. - (Annals of Neurology, ISSN 0364-5134) .
Langues : Anglais Langues originales : Anglais
Catégories : Démences:Maladie d'Alzheimer
Sciences:RechercheTags : Recherche médicale, Microglies, Alzheimer Résumé :
Abstract
Objective
Because the role of white matter (WM) degenerating microglia (DM) in remyelination failure is unclear, we sought to define the core features of this novel population of aging human microglia.
Methods
We analyzed postmortem human brain tissue to define a population of DM in aging WM lesions. We used immunofluorescence staining and gene expression analysis to investigate molecular mechanisms related to the degeneration of DM.
Results
We found that DM, which accumulated myelin debris were selectively enriched in the iron-binding protein light chain ferritin, and accumulated PLIN2-labeled lipid droplets. DM displayed lipid peroxidation injury and enhanced expression for TOM20, a mitochondrial translocase, and a sensor of oxidative stress. DM also displayed enhanced expression of the DNA fragmentation marker phospho-histone H2A.X. We identified a unique set of ferroptosis-related genes involving iron-mediated lipid dysmetabolism and oxidative stress that were preferentially expressed in WM injury relative to gray matter neurodegeneration.
Interpretation
Ferroptosis appears to be a major mechanism of WM injury in Alzheimer's disease and vascular dementia. WM DM are a novel therapeutic target to potentially reduce the impact of WM injury and myelin loss on the progression of cognitive impairment. ANN NEUROL 2023
En ligne : https://doi.org/10.1002/ana.26770 SupplémentsRéservation
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