Titre : | The impact of routine vaccinations on Alzheimer's disease risk in persons 65 years and older : a claims-based cohort study using propensity score matching | Type de document : | texte imprimé | Auteurs : | Kristofer Harris (19.. - ....), Auteur ; Yaobin Ling (19.. - ....), Auteur ; Avram S. Bukhbinder (19.. - ....), Auteur | Editeur : | Amsterdam : IOS Press | Année de publication : | 2023 | Importance : | 16 p. | Format : | 30cm | Note générale : | Article scientifique publié en Open Access dans le magazine Journal of Alzheimer's Disease vol. 95 n°2 | Langues : | Anglais Langues originales : Anglais | Catégories : | Démences:Maladie d'Alzheimer Sciences:Recherche
| Tags : | Recherche médicale, Vaccin, Vaccination | Résumé : | Abstract. Background: Accumulating evidence suggests that adult vaccinations can reduce the risk of developing Alzheimer’s disease (AD) and Alzheimer’s disease related dementias. Objective: To compare the risk for developing AD between adults with and without prior vaccination against tetanus and diphtheria, with or without pertussis (Tdap/Td); herpes zoster (HZ); or pneumococcus. Methods: A retrospective cohort study was performed using Optum’s de-identified Clinformatics® Data Mart Database. Included patients were free of dementia during a 2-year look-back period and were ≥ 65 years old by the start of the 8-year follow-up period. We compared two similar cohorts identified using propensity score matching (PSM), one vaccinated and another unvaccinated, with Tdap/Td, HZ, or pneumococcal vaccines. We calculated the relative risk (RR) and absolute risk reduction (ARR) for developing AD. Results: For the Tdap/Td vaccine, 7.2% (n = 8,370) of vaccinated patients and 10.2% (n = 11,857) of unvaccinated patients developed AD during follow-up; the RR was 0.70 (95% CI, 0.68–0.72) and ARR was 0.03 (95% CI, 0.02–0.03). For the HZ vaccine, 8.1% (n = 16,106) of vaccinated patients and 10.7% (n = 21,417) of unvaccinated patients developed AD during follow-up; the RR was 0.75 (95% CI, 0.73–0.76) and ARR was 0.02 (95% CI, 0.02–0.02). For the pneumococcal vaccine, 7.92% (n = 20,583) of vaccinated patients and 10.9% (n = 28,558) of unvaccinated patients developed AD during follow-up; the RR was 0.73 (95% CI, 0.71–0.74) and ARR was 0.02 (95% CI, 0.02–0.03). Conclusion: Several vaccinations, including Tdap/Td, HZ, and pneumococcal, are associated with a reduced risk for developing AD. | En ligne : | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad221231 |
The impact of routine vaccinations on Alzheimer's disease risk in persons 65 years and older : a claims-based cohort study using propensity score matching [texte imprimé] / Kristofer Harris (19.. - ....), Auteur ; Yaobin Ling (19.. - ....), Auteur ; Avram S. Bukhbinder (19.. - ....), Auteur . - Amsterdam : IOS Press, 2023 . - 16 p. ; 30cm. Article scientifique publié en Open Access dans le magazine Journal of Alzheimer's Disease vol. 95 n°2 Langues : Anglais Langues originales : Anglais Catégories : | Démences:Maladie d'Alzheimer Sciences:Recherche
| Tags : | Recherche médicale, Vaccin, Vaccination | Résumé : | Abstract. Background: Accumulating evidence suggests that adult vaccinations can reduce the risk of developing Alzheimer’s disease (AD) and Alzheimer’s disease related dementias. Objective: To compare the risk for developing AD between adults with and without prior vaccination against tetanus and diphtheria, with or without pertussis (Tdap/Td); herpes zoster (HZ); or pneumococcus. Methods: A retrospective cohort study was performed using Optum’s de-identified Clinformatics® Data Mart Database. Included patients were free of dementia during a 2-year look-back period and were ≥ 65 years old by the start of the 8-year follow-up period. We compared two similar cohorts identified using propensity score matching (PSM), one vaccinated and another unvaccinated, with Tdap/Td, HZ, or pneumococcal vaccines. We calculated the relative risk (RR) and absolute risk reduction (ARR) for developing AD. Results: For the Tdap/Td vaccine, 7.2% (n = 8,370) of vaccinated patients and 10.2% (n = 11,857) of unvaccinated patients developed AD during follow-up; the RR was 0.70 (95% CI, 0.68–0.72) and ARR was 0.03 (95% CI, 0.02–0.03). For the HZ vaccine, 8.1% (n = 16,106) of vaccinated patients and 10.7% (n = 21,417) of unvaccinated patients developed AD during follow-up; the RR was 0.75 (95% CI, 0.73–0.76) and ARR was 0.02 (95% CI, 0.02–0.02). For the pneumococcal vaccine, 7.92% (n = 20,583) of vaccinated patients and 10.9% (n = 28,558) of unvaccinated patients developed AD during follow-up; the RR was 0.73 (95% CI, 0.71–0.74) and ARR was 0.02 (95% CI, 0.02–0.03). Conclusion: Several vaccinations, including Tdap/Td, HZ, and pneumococcal, are associated with a reduced risk for developing AD. | En ligne : | https://content.iospress.com/articles/journal-of-alzheimers-disease/jad221231 |
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