Diet modulates brain network stability, a biomarker for brain aging, in young adults / Liliane R. Mujica-Parodi  

Public ISBD Accompagne Quelle alimentation ralentit le vieillissement du cerveau ? / Juliette Pouyat Titre : Diet modulates brain network stability, a biomarker for brain aging, in young adults Type de document : document électronique Auteurs : Liliane R. Mujica-Parodi, Auteur ; Anar Amgalan, Auteur ; Syed Fahad Sultan, Auteur Editeur : Washington : National Academy of Sciences Année de publication : 2020 Importance : 1 page web Langues : Anglais Catégories : Alimentation et nutrition Anatomie:système nerveux:Cerveau Biomarqueurs Diagnostic:Diagnostic par imagerie:Neuroimagerie Psychiatrie:Troubles mentaux:Troubles de la cognition Santé:Maladies:Maladies du système nerveux Vieillissement Vieillissement:Vieillissement cognitif Tags : Cerveau  Vieillissement  Vieillissement cognitif  Alimentation et nutrition  Troubles de la cognition  Neuroimagerie  Maladies du système nerveux  Biomarqueurs Résumé : To better understand how diet influences brain aging, we focus here on the presymptomatic period during which prevention may be most effective. Large-scale life span neuroimaging datasets show functional communication between brain regions destabilizes with age, typically starting in the late 40s, and that destabilization correlates with poorer cognition and accelerates with insulin resistance. Targeted experiments show that this biomarker for brain aging is reliably modulated with consumption of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks. This effect replicated across both changes to total diet as well as fuel-specific calorie-matched bolus, producing changes in overall brain activity that suggest that network “switching” may reflect the brain’s adaptive response to conserve energy under resource constraint. En ligne : https://www.pnas.org/content/pnas/early/2020/03/02/1913042117.full.pdf Format de la ressource électronique : WEB Accompagne Quelle alimentation ralentit le vieillissement du cerveau ? / Juliette Pouyat Diet modulates brain network stability, a biomarker for brain aging, in young adults [document électronique] / Liliane R. Mujica-Parodi, Auteur ; Anar Amgalan, Auteur ; Syed Fahad Sultan, Auteur . - Washington : National Academy of Sciences, 2020 . - 1 page web. Langues : Anglais Catégories : Alimentation et nutrition Anatomie:système nerveux:Cerveau Biomarqueurs Diagnostic:Diagnostic par imagerie:Neuroimagerie Psychiatrie:Troubles mentaux:Troubles de la cognition Santé:Maladies:Maladies du système nerveux Vieillissement Vieillissement:Vieillissement cognitif Tags : Cerveau  Vieillissement  Vieillissement cognitif  Alimentation et nutrition  Troubles de la cognition  Neuroimagerie  Maladies du système nerveux  Biomarqueurs Résumé : To better understand how diet influences brain aging, we focus here on the presymptomatic period during which prevention may be most effective. Large-scale life span neuroimaging datasets show functional communication between brain regions destabilizes with age, typically starting in the late 40s, and that destabilization correlates with poorer cognition and accelerates with insulin resistance. Targeted experiments show that this biomarker for brain aging is reliably modulated with consumption of different fuel sources: Glucose decreases, and ketones increase the stability of brain networks. This effect replicated across both changes to total diet as well as fuel-specific calorie-matched bolus, producing changes in overall brain activity that suggest that network “switching” may reflect the brain’s adaptive response to conserve energy under resource constraint. En ligne : https://www.pnas.org/content/pnas/early/2020/03/02/1913042117.full.pdf Format de la ressource électronique : WEB

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